Communication and Swallowing Outcomes in Patients With Acquired and Progressive Neurological Disorders

Development and validation of the dysarthria impact scale: a patient-reported outcome for motor speech disorders

AP Vogel, L Graf, M Weiß, CSJ Chan, G Hepworth, M Synofzik

2026-03-01

Background: Impaired speech due to dysarthria significantly impacts quality of life. Patient-reported outcomes (PROs) offer critic..

Optimising verbal fluency analysis in neurological patients with dysarthria: examples from Parkinson’s disease and hereditary ataxia

Y Li, J Yang, K Evans, J Bow-Wah Wong, NN Dissanayaka, AP Vogel

2023-01-01

Background: Verbal fluency tests (VFTs) are widely used to assess cognitive-linguistic performance in neurological diseases. Howev..

Home-based biofeedback speech treatment improves dysarthria in repeat-expansion SCAs

AP Vogel, LH Graf, M Magee, L Schöls, N Rommel, M Synofzik

2022-08-01

CAG repeat-expansion spinocerebellar ataxias (CAG-SCAs) are genetically defined multisystemic degenerative diseases, resulting in ..

Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis

G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van der Walt, AP Vogel

2021-01-01

Background and purpose: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis..

Acoustic Speech Analytics Are Predictive of Cerebellar Dysfunction in Multiple Sclerosis

G Noffs, FMC Boonstra, T Perera, SC Kolbe, J Stankovich, H Butzkueven, A Evans, AP Vogel, A van der Walt

2020-10-01

Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cer..

Imaging and Clinical Data on Swallowing Function of Individuals with Huntington's Disease and Dysphagia

M Keage, S Baum, L Pointon, J Lau, J Berndt, J Hopkins, R Maule, AP Vogel

2020-01-01

Background: Dysphagia is common in Huntington's disease (HD) affecting all phases of swallowing. Correlations exist between non-in..

Quantifying ultrasonic mouse vocalizations using acoustic analysis in a supervised statistical machine learning framework

AP Vogel, A Tsanas, ML Scattoni

2019-12-01

Examination of rodent vocalizations in experimental conditions can yield valuable insights into how disease manifests and progress..

Speech treatment improves dysarthria in multisystemic ataxia: a rater-blinded, controlled pilot-study in ARSACS

AP Vogel, LH Stoll, A Oettinger, N Rommel, EM Kraus, D Timmann, D Scott, C Atay, E Storey, L Schöls, M Synofzik

2019-05-01

We aimed to provide proof-of-principle evidence that intensive home-based speech treatment can improve dysarthria in complex multi..

Interventions to Mitigate Bias in Social Work Decision-Making: A Systematic Review

R Featherston, A Shlonsky, C Lewis, ML Luong, L Downie, A Vogel, C Granger, B Hamilton, K Galvin

2019-01-01

Purpose: This systematic review synthesized evidence supporting interventions aimed at mitigating cognitive bias associated with t..

Validation of a precision tremor measurement system for multiple sclerosis

T Perera, WL Lee, SAC Yohanandan, AL Nguyen, B Cruse, FMC Boonstra, G Noffs, AP Vogel, SC Kolbe, H Butzkueven, A Evans, A van der Walt

2019-01-01

Background: Tremor is a debilitating symptom of Multiple Sclerosis (MS). Little is known about its pathophysiology and treatments ..

Coordination and timing deficits in speech and swallowing in autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS)

AP Vogel, N Rommel, A Oettinger, LH Stoll, EM Kraus, C Gagnon, M Horger, P Krumm, D Timmann, E Storey, L Schöls, M Synofzik

2018-09-01

Background: Autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is a rare early onset neurodegenerative disease tha..

Validation and Psychometric Properties of the German Version of the SWAL-QOL

EM Kraus, N Rommel, LH Stoll, A Oettinger, AP Vogel, M Synofzik

2018-08-01

The SWAL-QOL questionnaire is a common tool for evaluating patients’ dysphagia-specific quality of life. A validated German versio..

Novel functional MRI task for studying the neural correlates of upper limb tremor

FMC Boonstra, T Perera, G Noffs, C Marotta, AP Vogel, AH Evans, H Butzkueven, BA Moffat, A van der Walt, SC Kolbe

2018-07-02

Introduction: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is curren..

Perception of cantonese lexical tones by pediatric cochlear implant users

CM Holt, KYS Lee, RC Dowell, AP Vogel

2018-01-01

Purpose: The purpose of this study is to assess Cantonese word recognition and the discrimination of Cantonese tones with manipula..

Objective analysis of speech correlates with disease severity in Multiple Sclerosis and differentiates groups with and without upper limb tremor

Gustavo Noffs, Frederique Boonstra, Thushara Perera, Scott C Kolbe, Camille J Shanahan, Andrew Evans, Helmut Butzkueven, Adam P Vogel, Anneke van der Walt

2017-11-01

Background: Dysarthria is highly prevalent in Multiple Sclerosis. The relationship between dysarthria, MS disease severity and oth..

Pathophysiology of MS tremor: an fMRI study

Frederique Boonstra, Gustavo Noffs, Thushara Perera, Camille Shanahan, Adam Vogel, Andrew Evans, Helmut Butzkueven, Anneke van der Walt, Scott Kolbe

2017-11-01

Speech and swallowing abnormalities in adults with POLG associated ataxia (POLG-A)

AP Vogel, N Rommel, A Oettinger, M Horger, P Krumm, EM Kraus, L Schöls, M Synofzik

2017-11-01

Background Mutations in the nuclear-encoded mitochondrial DNA polymerase gamma (POLG) can result in a wide spectrum of neurologica..

Dysphagia in Friedreich Ataxia

MJ Keage, MB Delatycki, I Gupta, LA Corben, AP Vogel

2017-10-01

The objective of the study was to comprehensively characterise dysphagia in Friedreich ataxia (FRDA) and identify predictors of pe..

Objective speech marker correlates with clinical scores in non-dysarthric MS

G Noffs, F Boonstra, S Kolbe, T Perera, C Shanahan, A Evans, H Butzkueven, A Vogel, A Van der Walt

2017-10-01

Background: Reduction of brain volume occurs in clinically active disease and correlates with progressive disability in multiple S..

Pathophysiology of MS tremor: an fMRI study

FMC Boonstra, G Noffs, T Perera, CJ Shanahan, AP Vogel, A Evans, H Butzkueven, A van der Walt, SC Kolbe

2017-10-01

Subclinical speech signs correlate with MS disease severity and differentiates patients with and without clinical cerebellar dysfunction

G Noffs, F Boonstra, T Perera, S Kolbe, C Shanahan, A Evans, H Butzkueven, A Vogel, A van der Walt

2017-10-01

Background: Dysarthria is highly prevalent in Multiple Sclerosis (MS). The relationship between dysarthria, MS disease severity an..

The history of stuttering by 7 years of age: Follow-up of a prospective community cohort

E Kefalianos, M Onslow, A Packman, A Vogel, A Pezic, F Mensah, L Conway, E Bavin, S Block, S Reilly

2017-10-01

Purpose: For a community cohort of children confirmed to have stuttered by the age of 4 years, we report (a) the recovery rate fro..

History of cannabis use is associated with altered gait

V Pearson-Dennett, G Todd, RA Wilcox, AP Vogel, JM White, D Thewlis

2017-09-01

Background Despite evidence that cannabinoid receptors are located in movement-related brain regions (e.g., basal ganglia, cerebra..

Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype

AP Vogel, ML Poole, H Pemberton, MWJ Caverlé, FMC Boonstra, E Low, D Darby, A Brodtmann

2017-08-22

Objective: To provide a comprehensive description of motor speech function in behavioral variant frontotemporal dementia (bvFTD). ..

Clinical assessment of dysphagia in neurodegeneration (CADN): development, validity and reliability of a bedside tool for dysphagia assessment

AP Vogel, N Rommel, C Sauer, M Horger, P Krumm, M Himmelbach, M Synofzik

2017-06-01

Screening assessments for dysphagia are essential in neurodegenerative disease. Yet there are no purpose-built tools to quantify s..

Speech as a reliable marker of alertness and performance impairment under conditions of acute sleep deprivation

S Ftouni, AP Vogel, WR McMahon, SW Lockley, S Rajaratnam, C Anderson

2017-04-28

The acoustic properties of speech are a reliable marker of changes in the central nervous system. Measures of speech timing and fr..

Motor speech phenotypes of frontotemporal dementia, primary progressive Aphasia, and progressive Apraxia of speech

ML Poole, A Brodtmann, D Darby, AP Vogel

2017-04-01

Purpose: Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressi..

Language, meaning, and localization: Last year s words, next year s words

A Brodtmann, AP Vogel

2017-03-07

Neurologic practice is deeply rooted in the ideal of localization. Some would argue that neurology arose in the mid-18th century f..

Voice in Friedreich Ataxia

AP Vogel, MI Wardrop, JE Folker, M Synofzik, LA Corben, MB Delatycki, SN Awan

2017-03-01

Background Friedreich Ataxia (FRDA) is the most common hereditary ataxia, with dysarthria as one of its key clinical signs. Object..

Cantonese tone perception for children who use a hearing aid and a cochlear implant in opposite ears

M Mok, CM Holt, KYS Lee, RC Dowell, AP Vogel

2017-01-01

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objectives: The ability to recognize tones is vital for speech p..

Efficacy of Parkinsong Groups for improving Communication and Wellbeing in Parkinson's Disease

Jeanette Tamplin, Adam Vogel, Caterina Marigliani, Felicity A Baker, Jane Davidson, Meg E Morris

2017-01-01

Communication impairment is one of the most common symptoms of Parkinson’s disease, significantly impacting quality of life (Mille..

Quantification of motor speech in primary progressive aphasia and frontotemporal dementia

M Poole

2017-01-01

Frontotemporal dementia (FTD) and primary progressive aphasia (PPA) are two groups of related disorders which are classified into ..

Speech outcomes in Parkinson's disease after subthalamic nucleus deep brain stimulation: A systematic review

D Aldridge, D Theodoros, A Angwin, AP Vogel

2016-12-01

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms for many individuals with Pa..

Atypical meningioma mimicking high-grade glioma Response

Adam P Vogel, Andrew Churchyard, Julie Stout

2016-11-22

Two different phenomena in basic motor speech performance in premanifest Huntington disease: Author response

Adam P Vogel, Carsten Saft, Andrew Churchyard, Julie Stout

2016-11-22

Stuck in the middle: The emotional labours of case managers in the personal injury compensation system

S Newnam, A Petersen, H Keleher, A Collie, A Vogel, R McClure

2016-10-17

BACKGROUND: Case managers within injury compensation systems are confronted with various emotional demands. OBJECTIVE: Employing t..

Mandarin lexical tone acquisition in cochlear implant users with prelingual deafness: A review

J Tan, R Dowell, A Vogel

2016-09-01

Purpose: The purpose of this review article is to synthesize evidence from the fields of developmental linguistics and cochlear im..

Validation of the tremor biomechanics analysis laboratory (TREMBAL) software in MS tremor

A Van der Walt, FMC Boonstra, SAC Yohanandan, AP Vogel, SC Kolbe, J Ly, G Noffs, H Butzkueven, AH Evans, T Perera

2016-09-01

Type: Poster Abstract Category: Clinical aspects of MS - Clinical assessment tools Background: Tremor in MS (MST) is difficult t..

Quantification of motor speech in primary progressive aphasia and frontotemporal dementia

M Poole, A Brodtmann, D Darby, A Vogel

2016-08-01

Frontotemporal dementia (FTD) and primary progressive aphasia (PPA) are two groups of related disorders which are classified into ..

Diagnostic Distortions: A Case Report of Progressive Apraxia of Speech

A Brodtmann, H Pemberton, D Darby, AP Vogel

2016-06-22

Apraxia of speech (AOS) can be the presenting symptom of neurodegenerative disease. The position of primary progressive AOS in the..

Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism

G Todd, V Pearson-Dennett, RA Wilcox, MT Chau, K Thoirs, D Thewlis, AP Vogel, JM White

2016-04-01

Introduction The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults..

A predictive model for diagnosing stroke-related apraxia of speech

KJ Ballard, L Azizi, JR Duffy, MR McNeil, M Halaki, N O'Dwyer, C Layfield, DI Scholl, AP Vogel, DA Robin

2016-01-29

Diagnosis of the speech motor planning/programming disorder, apraxia of speech (AOS), has proven challenging, largely due to its c..

Acoustic monitoring of speech impairment in motor neuron disease associated with frontotemporal dementia: a case series

A VOGEL, M Poole, D Darby, A Brodtmann

2016-01-01

Frontotemporal dementia is the second most common form of younger onset dementia. A subset of people with this disorder develop mo..

Clinical assessment of dysphagia in neurodegeneration (CADN): reliability and validity

A VOGEL, N Rommel, E Sauer, M Synofzik

2016-01-01

Background and aims: Progressive neurological disease typically results in swallowing deficits (dysphagia). Current tools used to ..

Exploring the influence of compensable injury on recovery

Amy R Allen, Sharon Newnam, Alan Petersen, Adam P Vogel, Alex Collie

2016-01-01

BACKGROUND: Compensable injury is a public health concern and understanding of the factors influencing recovery is crucial to impr..

Hello harlie: Enabling speech monitoring through chat-bot conversations

D Ireland, C Atay, J Liddle, D Bradford, H Lee, O Rushin, T Mullins, D Angus, J Wiles, S McBride, A Vogel

2016-01-01

People with neurological conditions such as Parkinson's disease and dementia are known to have difficulties in language and commun..

Speech disorder is an invisible form of disability

AP Vogel

2016-01-01

Video game-based speech rehabilitation for reducing dysarthria severity in adults with degenerative ataxia

A VOGEL, J Skarrat, J Castles, M Synofzik

2016-01-01

Background and aims: Dysarthria affects all individuals with degenerative ataxia. No treatments halt or reverse the effects of dis..

Treatment for dysphagia (swallowing difficulties) in hereditary ataxia

AP Vogel, MJ Keage, K Johansson, E Schalling

2015-11-13

Background: Hereditary ataxias are a heterogeneous group of disorders resulting in progressive inco-ordination. Swallowing impairm..

An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels

EM Yiu, G Tai, RE Peverill, KJ Lee, KD Croft, TA Mori, B Scheiber-Mojdehkar, B Sturm, M Praschberger, AP Vogel, G Rance, SEM Stephenson, JP Sarsero, C Stockley, CYJ Lee, A Churchyard, MV Evans-Galea, MM Ryan, PJ Lockhart, LA Corben

2015-05-26

Friedreich ataxia (FRDA) is due to a triplet repeat expansion in FXN, resulting in deficiency of the mitochondrial protein frataxi..

Feasibility of automated speech sample collection with stuttering children using interactive voice response (IVR) technology

AP Vogel, S Block, E Kefalianos, M Onslow, P Eadie, B Barth, L Conway, JC Mundt, S Reilly

2015-04-01

Purpose: To investigate the feasibility of adopting automated interactive voice response (IVR) technology for remotely capturing s..

Development of precise tremor assessment software to aid deep brain stimulation parameter optimization

Thushara Perera, Shivanthan AC Yohanandan, Adam P Vogel, Colette M McKay, Hugh J McDermott

2015-03-01

A Systematic Review of Self-reported Swallowing Assessments in Progressive Neurological Disorders

M Keage, M Delatycki, L Corben, A Vogel

2015-02-01

Dysphagia experienced as a consequence of neurodegenerative disease can have severe consequences on a patient’s health and well-be..

Deep brain stimulation wash-in and wash-out times for tremor and speech

Thushara Perera, Shivanthan AC Yohanandan, Adam P Vogel, Colette M McKay, Mary Jones, Richard Peppard, Hugh J McDermott

2015-01-01

Parkinson’s disease (PD) and Essential Tremor (ET) are progressive conditions with high world-wide prevalence. Deep Brain Stimulat..

Dysphagia in spinocerebellar ataxia and multiple system atrophy-cerebellar

Adam P Vogel, Lori Fendel, K Paige Brubacher, Victoria Chan, Roxanne Maule

2015-01-01

Dysphagia is a common sequelae of spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar (MSA-C) resulting in signifi..

Nasality in Friedreich ataxia

ML Poole, JS Wee, JE Folker, LA Corben, MB Delatycki, AP Vogel

2015-01-01

Perceptual speech research in Friedreich ataxia (FRDA) has identified altered nasality as a key component of the dysarthria profil..

The feasibility of using acoustic markers of speech for optimizing patient outcomes during randomized amplitude variation in deep brain stimulation: a proof of principle methods study

A Vogel, H Mcdermott, T Perera, M Jones, R Peppard, C McKay

2015-01-01

Background: Deep brain stimulation (DBS) is an effective treatment for reducing symptoms of tremor. A common and typically subject..

The influence of rate of stimulation and pulse duration on efficacy of deep brain stimulation for Essential Tremor

CM McKay, HJ McDermott, T Perera, R Peppard, M Jones, AP Vogel

2015-01-01

Deep brain stimulation (DBS) is used to alleviate tremor in patients diagnosed with Essential Tremor who do not respond to convent..

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes (Review)

A VOGEL, J Folker, null Poole ML

2014-12-01

Background: Hereditary ataxia syndromes can result in significant speech impairment, a symptom thought to be responsive to treatme..

Consensus clinical management guidelines for Friedreich ataxia

LA Corben, D Lynch, M Pandolfo, JB Schulz, MB Delatycki

2014-01-01

Friedreich ataxia (FRDA), a multisystem autosomal recessive condition, is the most common inherited ataxia in Caucasians, affectin..

Monitoring change requires a rethink of assessment practices in voice and speech

AP Vogel, P Maruff

2014-01-01

Assessment for the purpose of monitoring change over time requires a different practical and statistical approach to that of asses..